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Nanette Santoro, Laura T. To examine the relationship between endometrial histological maturation and reproductive hormones, we studied 11 fertile women, aged 18—37 yr. All participants had had at least 1 previous pregnancy and cycled regularly, every 25—35 days. Women collected daily, first morning voided urine for measurement of estradiol and progesterone metabolite excretion, estrone conjugates E1c , and pregnanediol glucuronide Pdg , respectively, throughout the cycle of study. Hormones were normalized for creatinine. Between 7—9 days after home detection of a LH surge Sure Step , participants underwent an endometrial biopsy using a small bore Pipelle catheter. Tissue was prepared for histological and biochemical analyses.
The Endometrium pp Cite as. The two ovarian hormones, estradiol and progesterone, induce profound morphologic changes in the endometrium. Classic histological techniques enabled detailed description of these alterations very early and extensive studies have permitted the dating of endometrial biopsy and precise pathology Noyes et al. According to these studies, the most relevant endometrial changes deal with stromal reorganization; however, more recently, electron microscopic studies have revealed subtle changes in the luminal surface epithelium for reviews see Borell et al. Unable to display preview. Download preview PDF.
Nevertheless, there is no consensus regarding the most suitable period of the luteal phase for performing the biopsy. OBJETIVE: This study evaluated the correlation between the histological dating of two endometrial biopsies performed in the same menstrual cycle, on luteal phase days six and ten. Dating was done according to morphometric criteria, in which an endometrium sample is considered out of phase if the minimum maturation delay is one day.